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Hallmarks of Cancer

  • Self-sufficiency in Growth Signals- Cancer cells are not dependent on normal growth factor signals.

  • Insensitivity to Anti-Growth Signals- Cancer cells do not respond to growth inhibitory signals

  • Tissue invasion and metastasis- Alterations of the genome may affect the activity the activity and levels of enzymes involved in invasion

  • Limitless Replicative potential- Cancer cells remain the length of their telomeres

  • Sustained angiogenesis- The formation of new blood vessels that spreads the tumor throughout the body

  • Evading Apoptosis- Cancer cells evade apoptotic signals

 

 

More information can be found in the articles below,

  • The Hallmarks of Cancer 

            http://www.sciencedirect.com/science/article/pii/S0092867400816839

  • Hallmarks of Cancer: The Next Generation; 

            http://www.sciencedirect.com/science/article/pii/S0092867411001279

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